War between the Nibblonians and the brain spawn

The war between the Nibblonians and the Brain Spawn was an immense conflict which began milliseconds after the Big Bang when the Brain Spawn were created. Their only goal was to learn all knowledge of the universe before destroying it, they apparently killed several species, or at least the Dinosaurs. By 1999, the Brain Spawn built an immense center of knowledge, the Infosphere. Nibbler, one of the Nibblonians, asks for a pizza from Panucci's Pizza as someone called "I. C. Wiener" so that the only person who can save the universe, Fry, will go to Applied Cryogenics for a delivery, and so Nibbler can freeze him for one thousand years in the freezing chamber.

In 3002 the Brain Spawn invaded Earth and made every human stupid with the exception of Fry who stopped the invasion, and the Nibblonians ate the last brains.

Later, in 3004, the Brain Spawn had nearly finished acquiring the knowledge of universe, but Nibbler sent Fry to activate the Quantum Interphase Bomb which propels the Infosphere and all Brain Spawn to a parallel universe from where it's impossible to return to our universe.