2001

In-Universe

 * The movie Jury Duty II: Trouble on the Hubble starring Pauly Shore released.
 * Fry's ex-girlfriend Michelle leaves her husband and family behind and freezes herself for 265 years (later changed to 990 by Lars), unaware that Fry has also been frozen.
 * Brain Spawn use the Infosphere to start 1000 year quest to obtain all knowledge in the universe.

Real World Production

 * January 21
 * Episode thirty four, Parasites Lost, is aired.
 * February 4
 * Episode thirty three, Amazon Women in the Mood, is aired.
 * February 11
 * Episode thirty eight, Bendless Love, is aired.
 * February 18
 * Episode thirty nine, The Day the Earth Stood Stupid, is aired.
 * February 25
 * Episode fourty, That's Lobstertainment!, is aired.
 * March 4
 * Episode thirty seven, The Birdbot of Ice-Catraz, is aired.
 * March 11
 * Episode thirty six, The Luck of the Fryrish, is aired.
 * April 1
 * Episode fourty one, The Cyber House Rules, is aired.
 * April 8
 * Episode fourty three, Insane in the Mainframe, is aired.
 * April 22
 * Episode fourty five, Bendin' in the Wind, is aired.
 * May 6
 * Episode fourty six, Time Keeps on Slippin', is aired.
 * May 13
 * Episode fourty seven, I Dated a Robot, is aired.
 * December 9
 * Episode fifty one, Roswell that Ends Well, is aired.
 * December 23
 * Episode thirty five, A Tale of Two Santas, is aired.