2001

In-Universe

 * The movie Jury Duty II: Trouble on the Hubble starring Pauly Shore released.
 * Fry's ex-girlfriend Michelle leaves her husband and family behind and freezes herself for 265 years (later changed to 990 by Lars), unaware that Fry has also been frozen.
 * Brain Spawn use the Infosphere to start 1000 year quest to obtain all knowledge in the universe.

Real World Production

 * 21 January
 * Episode thirty four, "Parasites Lost", is aired.
 * 4 February
 * Episode thirty three, "Amazon Women in the Mood", is aired.
 * 11 February
 * Episode thirty eight, "Bendless Love", is aired.
 * 18 February
 * Episode thirty nine, "The Day the Earth Stood Stupid", is aired.
 * 25 February
 * Episode fourty, "That's Lobstertainment!", is aired.
 * 4 March
 * Episode thirty seven, "The Birdbot of Ice-Catraz", is aired.
 * 11 March
 * Episode thirty six, "The Luck of the Fryrish", is aired.
 * 1 April
 * Episode fourty one, "The Cyber House Rules", is aired.
 * 8 April
 * Episode fourty three, "Insane in the Mainframe", is aired.
 * 22 April
 * Episode fourty five, "Bendin' in the Wind", is aired.
 * 6 May
 * Episode fourty six, "Time Keeps on Slippin'", is aired.
 * 13 May
 * Episode fourty seven, "I Dated a Robot", is aired.
 * 9 December
 * Episode fifty one, "Roswell that Ends Well", is aired.
 * 23 December
 * Episode thirty five, "A Tale of Two Santas", is aired.