Big Brain

The Big Brain was the mastermind of the Brain Spawn invasion of Earth. There may be several Big Brains, but only one was present at the invasion, and the Nibblonians implied that it was unique. It was instrumental in the attempted invasion and eradication of Earth and resided in New New York's Public Library during it, where it was fielded by Fry and Leela. The Big Brain has the ability to create fictional alternate realities (as found in books) and seal its enemies in it. Fry and Leela chased the brain through several literary classics like Moby Dick, Tom Sawyer and Pride and Prejudice. While it was distracted, Fry made use of this ability and wrote a short story of its own, thus shaping a fictional reality himself in which the Big Brain became trapped and did whatever he wrote. It then left Earth, and the Nibblonians seized the opportunity to destroy the invading Brain Spawn by devouring them. A Big Brain was present when the Brain Spawn created the Infosphere, though it may have been another Big Brain.

Like all other Brain Spawn, the Big Brain can stupefy all animals with the exception of Fry as he lacks Delta Brain Wave. It also has the ability to float.

Biography
No one knows when the Big Brain was created, it probably came into existence with the rest of its race shortly after the Big Bang and has roamed the universe ever since.

Trivia

 * In, Billy West notes that the voice that Maurice LaMarche does for the Big Brain is rather creepy.
 * LaMarche has also voiced a character named Brain in the  series .