|Location||New New York sewers, Earth|
|First appearance||"Leela's Homeworld" (4ACV02)|
Lake Mutagenic is a toxic, radioactive lake in the New New York sewers. When non-mutant DNA comes in contact with the liquid within, it is immediately mutated. It is apparently good for fishing and bathing in.
- "Leela's Homeworld" (4ACV02)
- "The Mutants Are Revolting" (6ACV12)