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|First appearance||"Kif Gets Knocked Up a Notch" (4ACV01)|
|Voiced by||Maurice LaMarche|
|Wikipedia has information unrelated to Futurama|
Professor James Moriarty is the main arch-enemy of Sherlock Holmes. In a Holo-Shed simulation, he, along with the rest of Zapp Brannigan's "History's Greatest Villains" came to life.
This is similar to an event in Star Trek: Star Trek: The Next Generation, where Professor Moriarty (a Holodeck simulation) became self-aware.