- Not to be confused with 2001: A Space Odyssey.
- Unknown date
- The movie Jury Duty II: Trouble on the Hubble, starring Pauly Shore, is released. [2ACV19]
- Fry's ex-girlfriend Michelle leaves her husband and family behind and freezes herself for 265 years [2ACV19] (later changed to 990 by Lars), [BBS] unaware that Fry has also been frozen.
- Brain spawn use the Infosphere to start a thousand-year quest to obtain all knowledge in the universe. [4ACV10]
- 21 January
- 24 January
- Comic two, "...But Deliver Us to Evil!", is released.
- 4 February
- Episode thirty-three, "Amazon Women in the Mood", is aired on FOX.
- 11 February
- Episode thirty-eight, "Bendless Love", is aired on FOX.
- 18 February
- Episode thirty-nine, "The Day the Earth Stood Stupid", is aired on FOX.
- 25 February
- Episode fourty, "That's Lobstertainment!", is aired on FOX.
- 4 March
- Episode thirty-seven, "The Birdbot of Ice-Catraz", is aired on FOX.
- 11 March
- Episode thirty-six, "The Luck of the Fryrish", is aired on FOX.
- 28 March
- Comic three, "The Owner of Mars Attacks!", is released.
- 1 April
- Episode fourty-one, "The Cyber House Rules", is aired on FOX.
- 8 April
- Episode fourty-three, "Insane in the Mainframe", is aired on FOX.
- 22 April
- Episode fourty-five, "Bendin' in the Wind", is aired on FOX.
- 6 May
- Episode fourty-six, "Time Keeps on Slippin'", is aired on FOX.
- 13 May
- Episode fourty-seven, "I Dated a Robot", is aired on FOX.
- 23 May
- Comic four, "DOOP the Right Thing!", is released.
- 25 July
- Comic five, "Who's Dying to Be a Gazillionaire?", is released.
- 24 October
- Comic six, "Xmas Time Is Fear", is released.
- 9 December
- Episode fifty-one, "Roswell that Ends Well", is aired on FOX.
- 23 December
- Episode thirty-five, "A Tale of Two Santas", is aired on FOX.